| Publication Type: | Journal Article |
| Year of Publication: | 1992 |
| Authors: | L. - J. Lin, Ruangrungsi, N., Cordell, G. A., Shieh, H. - L., You, M., Pezzuto, J. M. |
| Journal: | PhytochemistryPhytochemistry |
| Volume: | 31 |
| Pagination: | 4329-4331 |
| Keywords: | 12a-hydroxyrotenoid, 6-deoxyclitoriacetal, Clitoria macrophylla, COLOC NMR spectroscopy, cytotoxic activity., Leguminosae, roots |
| Abstract: | A new rotenoid, 6-deoxyclitoriacetal, was isolated from the roots of Clitoria macrophylla and its structural assignment was established unambiguously by a series of HETCOR, COLOC and NOE difference experiments. In vitro tests showed that this compound possessed strong cytotoxic activity against cultured P-388 lymphocytic leukemia cells, but was not active with cultured KB cells. However, marginal activity was observed with vinblastine-resistant KB-V1 cells, and this was enhanced by the addition of vinblastine. This rotenoid may, therefore, interact with P-glycoprotein. |
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